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中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
王萍,刘玉,王书,唐敏,周群.高龄脑白质疏松症患者危险因素分析及与糖尿病的相关性[J].中华老年多器官疾病杂志,2021,20(7):527~531
高龄脑白质疏松症患者危险因素分析及与糖尿病的相关性
Risk factors of leukoaraiosis severity in elderly patients and its correlation with diabetes mellitus
投稿时间:2020-09-27  
DOI:10.11915/j.issn.1671-5403.2021.07.110
中文关键词:  脑白质疏松症;糖尿病;糖化血红蛋白
英文关键词:leukoaraiosis; diabetes mellitus; hemoglobin A1c Corresponding author:WANG Ping, E-mail:wangping_198@163.com 〖FL
基金项目:
作者单位E-mail
王萍 安徽医科大学第三附属医院 老年病科,合肥 230013;合肥京东方医院神经内科,合肥 230061 wangping_198@163.comrisk 
刘玉 安徽医科大学第三附属医院 老年病科,合肥 230013 wangping_198@163.comrisk 
王书 安徽医科大学第三附属医院 老年病科,合肥 230013 wangping_198@163.comrisk 
唐敏 安徽医科大学第三附属医院 神经内科,合肥 230013 wangping_198@163.comrisk 
周群 安徽医科大学第三附属医院 神经内科,合肥 230013 wangping_198@163.comrisk 
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中文摘要:
      目的 探讨影响≥80岁患者脑白质疏松症(LA)严重程度的危险因素,分析糖尿病患者LA严重程度的特点。方法 选择2016年12月至2018年1月于安徽医科大学第三附属医院就诊的年龄≥80岁,经头颅磁共振成像证实存在LA的202例患者为研究对象。根据年龄相关性脑白质病变(ARWMC)评分对LA严重程度进行评估,比较不同等级LA患者的临床资料。根据入院时糖化血红蛋白(HbA1c)水平将糖尿病患者分为3组,比较3组患者的临床特征。采用SPSS 22.0统计软件对数据进行分析。根据数据类型分别采用单因素方差分析、χ2检验和秩和检验。LA相关危险因素采用logistic回归分析。结果 随着LA严重程度的增加,年龄呈升高趋势,糖尿病患病率上升,空腹血糖水平升高,组间比较,差异有统计学意义(P<0.05)。糖尿病组ARWMC评分[6.00(4.00,8.00)]明显高于非糖尿病组[4.00(3.00,6.00)] ,差异有统计学意义(P<0.001)。糖尿病组多元logistic回归分析显示,年龄、HbA1c水平升高是LA严重程度的独立危险因素。结论 高龄LA患者中,年龄、糖尿病与LA病变严重程度相关;合并糖尿病的高龄LA患者,HbA1c水平与LA严重程度独立相关。
英文摘要:
      Objective To investigate the risk factors for the severity of leukoaraiosis (LA) in patients aged ≥80 years and analyze the characteristics of LA in the diabetic patients. Methods Totally 202 patients aged≥80 years who were identified with LA by head MRI in the Third Affiliated Hospital of Anhui Medical University were recruited in this study. The severity of LA was assessed according to the rating scale for age-related white matter changes (ARWMC). The clinical baseline data were compared among the patients with different severities of LA. According to glycosylated hemoglobin A1c (HbA1c) at admission, the diabetic patients were further divided into 3 subgroups, and their clinical features were compared. SPSS statistics 22.0 was used to perform the statistical analysis. One-way ANONA, Chi-square test and rank sum test was employed for different data types. Related risk factors for LA were analyzed with logistic regression analysis. Results As the severity of LA increased, the age showed an increasing trend, the prevalence of diabetes was elevated, and the fasting blood glucose level was increased, statistical differences were seen among the three groups (P<0.05). The ARWMC score was obviously higher in the diabetic group than the non-diabetic group [6.00 (4.00,8.00) vs 4.00 (3.00,6.00), P<0.001]. Multinomial regression analysis found that age and HbA1c level were independent risk factors for LA severity in diabetic mellitus group. Conclusion In the very old patients with LA, age and diabetes are correlated with LA severity. In the elderly diabetic patients with LA, HbA1c level is independently correlated with LA severity.
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