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中国人民解放军总医院
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中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
陈辉,赵春芝,朱正太,李华.老年2型糖尿病患者中性粒细胞/淋巴细胞比值、脂蛋白相关磷脂酶A2与颈动脉内-中膜厚度的相关性[J].中华老年多器官疾病杂志,2020,19(12):914~918
老年2型糖尿病患者中性粒细胞/淋巴细胞比值、脂蛋白相关磷脂酶A2与颈动脉内-中膜厚度的相关性
Correlation between neutrophil-lymphocyte ratio and lipoprotein-associated phospholipase A2 and carotid intima-media thickness in elderly patients with type 2 diabetes mellitus
投稿时间:2020-03-22  
DOI:10.11915/j.issn.1671-5403.2020.12.210
中文关键词:  老年人;糖尿病,2型;颈动脉内-中膜厚度;中性粒细胞/淋巴细胞比值;脂蛋白相关磷脂酶A2
英文关键词:aged; diabetes mellitus, type 2 ; carotid intima-media thickness; neutrophil/lymphocyte ratio; lipoprotein-associated phospholipase A2 Corresponding author:CHEN Hui, E-mail:chenhuichenping@163.com〖FL
基金项目:
作者单位E-mail
陈辉 泰州市人民医院老年医学科,江苏 泰州 225300 chenhuichenping@163.comcorrelation 
赵春芝 泰州市人民医院老年医学科,江苏 泰州 225300 chenhuichenping@163.comcorrelation 
朱正太 泰州市人民医院老年医学科,江苏 泰州 225300 chenhuichenping@163.comcorrelation 
李华 泰州市人民医院老年医学科,江苏 泰州 225300 chenhuichenping@163.comcorrelation 
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中文摘要:
      目的 探讨老年2型糖尿病(T2DM)患者中性粒细胞/淋巴细胞比值(NLR)、脂蛋白相关磷脂酶A2(LP-PLA2)与颈动脉内-中膜厚度(CIMT)的关系。方法 选取2018年1月至2020年1月于泰州市人民医院老年科和内分泌科住院的老年T2DM患者276例,CIMT<1.0 mm 为正常组(NCIMT组,n=138);CIMT≥1.0 mm为增厚组(ACIMT 组,n=138)。同期选取135名健康体检者为对照(NC)组。检测各组临床生化指标、血常规和血浆LP-PLA2。采用SPSS 20.0软件进行数据分析。分别采用单因素方差分析、Kruskal-Wallis H 检验进行组间数据比较,采用偏相关分析NLR、LP-PLA2与各指标的相关性,采用多元逐步回归分析CIMT增厚的危险因素。结果 和NC组相比,NCIMT组及ACIMT 组NLR和LP-PLA2均升高[NLR:(2.51±0.82)和(2.78±1.01)和(2.23±0.77);LP-PLA2:(142.80±37.24)和(154.78±45.92)和(130.17±39.37) ng/ml;均P<0.05],且ACIMT 组高于NCIMT 组。相关分析显示,NLR与收缩压、舒张压、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、CIMT呈正相关(P<0.05);LP-PLA2与总胆固醇、低密度脂蛋白胆固醇(LDL-C)、CIMT呈正相关(P<0.01);且LP-PLA2与NLR呈正相关(P<0.01)。多元逐步回归分析显示,CIMT的影响因素为糖尿病病程、FBG、HbA1c、LDL-C、NLR、LP-PLA2(β分别为0.009、0.028、0.032、0.036、0.069、0.001,P<0.05或P<0.01)。结论 NLR和LP-PLA2是老年T2DM患者CIMT增厚的危险因素,可能与老年T2DM患者动脉粥样硬化的发生发展有关。
英文摘要:
      Objective To explore the relationship between neutrophil/lymphocyte ratio (NLR) and lipoprotein-associated phospholipase A2 (LP-PLA2) and carotid intima-media thickness (CIMT) in elderly patients with type 2 diabetes mellitus (T2DM). Methods A total of 276 T2DM patients were enrolled in this study, who admitted to geriatric and endocrine departments of Taizhou People′s Hospital from January 2018 to January 2020 and were divided into two groups:normal CIMT group (CIMT<1.0 mm, NCIMT, n=138) and abnormal CIMT group (CIMT≥1.0 mm, ACIMT, n=138). Healthy individuals were enrolled as control group (NC, n=135). Clinical biochemical index, blood routine and plasma LP-PLA2 level were measured. SPSS statistics 20.0 was used for data analysis. Depending on different data types, one-way analysis of variance or Kruskal-Wallis H test was used for comparison between groups. Partial correlation was used to analyze the correlation between NLR and LP-PLA2 and each index. Multiple stepwise regression was performed for the risk factors of CIMT in the T2DM patients.Results NLR and LP-PLA2 levels were higher in NCIMT group and ACIMT group than in NC group [NLR:(2.51±0.82) vs (2.78±1.01) vs (2.23±0.77); LP-PLA2:(142.80±37.24) vs (154.78±45.92) vs (130.17±39.37) ng/ml; all P<0.05], and ACIMT group were higher than NCIMT group. Correlation analysis showed that NLR was positively correlated with systolic blood pressure, diastolic blood pressure, fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), and CIMT (P<0.05); LP-PLA2 was positively correlated with total cholesterol, low-density lipoprotein cholesterol (LDL-C), and CIMT (P<0.01); LP-PLA2 was positively correlated with NLR (P<0.01). Multiple stepwise regression analysis showed that the factors affecting CIMT were course of T2DM, FBG, HbA1c, LDL-C, NLR and LP-PLA2 (β=0.009, 0.028, 0.032,0.036,0.069,0.001, respectively; P<0.05 or P<0.01). Conclusion NLR and LP-PLA2 are risk factors of CIMT in elderly T2DM patients, and may be related to the occurrence and development of atherosclerosis in those patients.
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