在线办公
期刊论坛
主 管
中国人民解放军总医院
主 办
中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
编 辑
中华老年多器官疾病杂志编辑委员会
100853, 北京市复兴路28号
电话:010-66936756
传真:010-66936756
E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
李蓉华,张志花,李东芳.注射用丹参多酚酸对急性脑梗死的疗效及清除自由基的作用[J].中华老年多器官疾病杂志,2020,19(8):585~589
注射用丹参多酚酸对急性脑梗死的疗效及清除自由基的作用
Efficacy of salvianolic acid for injection in acute cerebral infarction and its sca-venging effect on free radicals
投稿时间:2019-08-26  
DOI:10.11915/j.issn.1671-5403.2020.08.137
中文关键词:  脑梗死;注射用丹参多酚酸;超氧化物歧化酶;丙二醛
英文关键词:cerebral infarction; salvianolic acid for injection; superoxide dismutase; malondialdehyde This work was supported by Wu Jieping Medical Foundation
基金项目:吴阶平医学基金(320.6750.18002)
作者单位E-mail
李蓉华 山西医科大学第二临床医院神经内科,太原 030000 lidongfang898@163.comefficacy 
张志花 山西医科大学第二临床医院神经内科,太原 030000 lidongfang898@163.comefficacy 
李东芳 山西医科大学第二临床医院神经内科,太原 030000 lidongfang898@163.comefficacy 
摘要点击次数: 34
全文下载次数: 42
中文摘要:
      目的 观察注射用丹参多酚酸对脑梗死急性期的疗效及其对氧自由基的作用。方法 将2017年2月至11月我院神经内科收治的急性脑梗死患者分为对照组(n=76)和研究组(n=67)。对照组予以脑梗死常规治疗,研究组在此基础上加用注射用丹参多酚酸(0.13g),2组均治疗2周。比较2组治疗前后神经功能缺损程度(NIHSS评分、mRS评分)变化、日常生活能力(BI指数)变化及血清丙二醛(MDA)、超氧化物歧化酶(SOD)浓度变化。采用SPSS 17.0软件进行统计学处理。采用t 检验、秩和检验或χ2检验对组间数据进行比较。结果 治疗前,2组基线资料比较差异无统计学意义(P>0.05)。治疗后研究组总有效率显著高于对照组(89.55%和67.11%),差异有统计学意义(χ2=43.64,P<0.01)。治疗后研究组较对照组NIHSS 评分[1(1,2)和2(1,4)分]、mRS 评分[1(1,2)和2(1,3)分]、BI 指数[100(85,100)和 90(76,100)分]及3项评分好转率[0.7(0.4,0.8)和0.3(0.1,0.5);0.5(0.3,0.8)和0.3(0.0,0.5);-0.4(-0.6,-0.1)和-0.1(-0.2,0.0)]均有改善,差异均有统计学意义(P<0.01)。治疗后研究组较对照组MDA [1.5(1,2) 和2(1,3)nmol/ml]显著下降,差异有统计学意义(P<0.01)。对照组治疗后SOD较治疗前[145.8(131.3,160.8)和143.6(128.7,153.9)U/ml]升高不明显,差异无统计学意义(P>0.05);研究组则升高显著[162.1(139.3,188.4)和149.9(131.3,167.3)U/ml],且研究组较对照组[162.1(139.3,188.4)和145.8(131.3,160.8)U/ml]显著升高,差异均有统计学意义(P<0.05,P<0.01)。结论 脑梗死急性期加用注射用丹参多酚酸治疗,可显著改善患者的神经功能缺损评分及日常生活能力,降低 MDA 水平,升高 SOD活力,具有抗氧化及清除自由基作用,从而改善临床预后。
英文摘要:
      Objective To investigate the efficacy of salvianolic acid for injection (SAFI) in acute cerebral infarction and its effect on oxygen free radicals. Methods The patients with acute cerebral infarction were collected from February 2017 to November 2017. The control group (n=76) received routine treatment of cerebral infarction and the study group (n=67) additional SAFI (0.13g), both groups for 2 weeks. The two groups were compared before and after treatment in the respects of degree of neurological deficit, including National Institute of Health Stroke Scale (NIHSS) score, modified Rankin Scale (mRS) score, Barthel index (BI) and change of serum malondialdehyde(MDA) and superoxide dismutase(SOD). SPSS statistics 17.0 was used for statistical analysis. Depending on data type, data comparison was made using t test, rank-sum test,or χ2 test. Results There was no significant difference in baseline data between the two groups before treatment (P>0.05). After treatment, the overall effective rate of the study group was significantly higher than that of the control group(89.55% vs 67.11%), the difference was statistically significant (χ2=43.64, P<0.01). After treatment, NIHSS score [1(1,2) vs 2(1,4) points], mRS score [1(1,2) vs 2(1,3) points], BI index [100(85,100) vs 90(76,100) points] and scores improvement rate[0.7(0.4,0.8) vs 0.3(0.1,0.5); 0.5(0.3,0.8) vs 0.3(0.0,0.5); -0.4(-0.6, -0.1) vs -0.1(-0.2,0.0)] of the study group were improved compared with the control group, the differences are statistically significant (P<0.01). After treatment, the MDA of the study group decreased compared with the control group [1.5(1,2) vs 2(1,3)nmol/ml], the difference was statistically significant (P<0.01). After treatment, SOD [145.8(131.3,160.8) vs 143.6(128.7,153.9)U/ml] did not increase significantly in the control group, the difference was not statistically significant (P>0.05); while SOD increased significantly after treatment in the study group, [162.1(139.3,188.4) vs 149.9(131.3,167.3)U/ml], and compared with the control group, SOD [162.1(139.3,188.4) vs 145.8(131.3,160.8)U/ml] were significantly higher in the study group, the differences were statistically significant (P<0.05, P<0.01). Conclusion SAFI can significantly improve the score of neurological deficit and the ability of daily life of patients with acute cerebral infarction.SAFI might play antioxidant roles and eliminate free radicals by decreasing MDA and increasing SOD activity, thereby improving clinical prognosis.
查看全文    下载PDF阅读器
关闭