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中国人民解放军总医院
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中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
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中华老年多器官疾病杂志编辑委员会
100853, 北京市复兴路28号
电话:010-66936756
传真:010-66936756
E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
李婉,田文.白细胞介素-6和前白蛋白与左心室射血分数保留心力衰竭的相关性[J].中华老年多器官疾病杂志,2019,18(9):670~673
白细胞介素-6和前白蛋白与左心室射血分数保留心力衰竭的相关性
Correlation of interleukin-6 and prealbumin with heart failure with preserved ejection fraction
投稿时间:2019-04-14  
DOI:10.11915/j.issn.1671-5403.2019.09.145
中文关键词:  白细胞介素-6;前白蛋白;心力衰竭
英文关键词:interleukin-6; pre-albumin; heart failure
基金项目:
作者单位E-mail
李婉 中国医科大学附属第一医院老年心血管内科,沈阳 110001  
田文 中国医科大学附属第一医院老年心血管内科,沈阳 110001 dr_wentian@163.com 
摘要点击次数: 58
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中文摘要:
      目的 探讨白细胞介素-6(IL-6)和前白蛋白(PA)与左心室射血分数保留心力衰竭(HF-PEF)的相关性。方法 回顾性分析2017年6月至2019年5月中国医科大学附属第一医院老年心血管内科HF-PEF患者126例,根据彩色多普勒超声心动图结果将患者分为左心室舒张功能减低组和左心室舒张功能正常组,每组63例,比较2组患者的IL-6、PA和脑钠肽(BNP)等生化指标水平。多因素logistic回归分析HF-PEF的影响因素。采用SPSS 22.0统计软件对数据进行分析。结果 左心室舒张功能减低组相比左心室舒张功能正常组年龄[(78.2±9.3)和(70.3±8.9)岁]、体质量指数[(25.2±3.4)和(23.8±2.8)kg/m2]、BNP[(115.0±128.9)和(46.7±59.5)pg/ml]、E/e′[(13.4±5.5)和(9.2±1.8)]、IL-6[(5.3±5.2)和(3.3±3.4)pg/ml]水平高,白蛋白[(38.9±3.8)和(40.7±3.8)g/L]、PA[(21.5±4.6)和(24.7±5.2)mg/dl]水平低,差异均有统计学意义(P<0.05)。Logistic回归分析结果表明年龄(OR=1.062,95%CI 1.007~1.119;P=0.026)及E/e′(OR=1.365,95%CI 1.127~1.653;P=0.002)与HF-PEF正相关,PA与HF-PEF负相关(OR=0.916,95%CI 0.842~0.997;P=0.043)。结论 HF-PEF与年龄及PA水平相关,检测PA可能有助于HF-PEF的早期诊断。
英文摘要:
      Objective To investigate the correlation of interleukin-6 (IL-6) and prealbumin (PA) with heart failure with preserved ejection fraction (HF-PEF). Methods A total of 126 HF-PEF patients admitted in our department from June 2017 to May 2019 were recruited, and their clinical data were collected and retrospectively analyzed. According to the results of echocardiography, the patients were divided into decreased left ventricular diastolic function group and normal left ventricular diastolic function group, with 63 patients in each group. The levels of IL-6, PA, brain natriuretic peptide (BNP) and other biochemical indicators were compared between the 2 groups. Multivariate logistic regression analysis was used to identify the influencing factors of HF-PEF. SPSS statistics 22.0 was used for data analysis. Results The decreased left ventricular diastolic function group had significantly older age [(78.2±9.3) vs (70.3±8.9)years], higher body mass index [(25.2±3.4) vs (23.8±2.8)kg/m2], increased E/e′ [(13.4±5.5) vs (9.2±1.8)] and elevated levels of BNP [(115.0±128.9) vs (46.7±59.5)pg/ml] and IL-6 [(5.3±5.2) vs (3.3±3.4)pg/ml], but obviously lower levels of albumin [(38.9±3.8) vs (40.7±3.8)g/L] and PA [(21.5±4.6) vs (24.7±5.2)mg/dl] when compared with the normal left ventricular diastolic function group (P<0.05). Logistic regression analysis showed that age (OR=1.062,5%CI 1.007-1.119; P=0.026) and E/e′(OR=1.365,5%CI 1.127-1.653; P=0.002) were positively correlated with HF-PEF, while PA was negatively correlated with HF-PEF (OR=0.916,5%CI 0.842-0.997; P=0.043). Conclusion HF-PEF is related to age and PA level. Detection of PA may be helpful to early diagnosis of HF-PEF.
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