在线办公
期刊论坛
主 管
中国人民解放军总医院
主 办
中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
编 辑
中华老年多器官疾病杂志编辑委员会
100853, 北京市复兴路28号
电话:010-66936756
传真:010-66936756
E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
王凯莉,孙子淇,吴伟华.2型糖尿病患者下肢动脉粥样硬化分级与中性粒细胞/淋巴细胞比值的关系[J].中华老年多器官疾病杂志,2019,18(9):656~660
2型糖尿病患者下肢动脉粥样硬化分级与中性粒细胞/淋巴细胞比值的关系
Relationship between atherosclerosis grade in lower extremities and neutrophil-lymphocyte ratio in patients with type 2 diabetes mellitus
  
DOI:10.11915/j.issn.1671-5403.2019.09.142
中文关键词:  糖尿病,2型;下肢动脉粥样硬化;中性粒细胞/淋巴细胞比值
英文关键词:type 2 diabetes; arteriosclerosis of lower extremities; neutrophil-lymphocyte ratio
基金项目:黑龙江省教育厅科学技术研究项目 (11541133)
作者单位E-mail
王凯莉 哈尔滨医科大学附属第一医院内分泌科,哈尔滨 150000  
孙子淇 哈尔滨医科大学附属第一医院内分泌科,哈尔滨 150000  
吴伟华 哈尔滨医科大学附属第一医院内分泌科,哈尔滨 150000 hui-90@163.com 
摘要点击次数: 52
全文下载次数: 70
中文摘要:
      目的 探索中性粒细胞/淋巴细胞比值(NLR)与2型糖尿病(T2DM)患者下肢动脉粥样硬化(AS)分级之间的关系。方法 入选2017年9月至2018年9月哈尔滨医科大学附属第一医院内分泌科住院的T2DM患者556例,根据AS分级分为4组:T2DM+AS1组140例(单纯T2DM患者),T2DM+AS2组98例,T2DM+AS3组192例,T2DM+AS4组126例。收集4组患者临床指标并进行比较。使用SPSS 17.0软件对数据进行统计分析。结果 4组患者年龄、性别、吸烟史、T2DM病程、高血压病史、收缩压、舒张压、中性粒细胞、淋巴细胞、NLR、肌酐、低密度脂蛋白胆固醇比较差异均有统计学意义(P<0.05)。Spearman相关性分析显示,在T2DM AS人群中,NLR与年龄、高血压病史、收缩压及肌酐呈显著正相关(P<0.05)。二分类logistic回归分析显示,年龄(OR=1.111,5%CI 1.076~1.147;P=0.001)、低密度脂蛋白胆固醇(OR=1.506,5%CI 1.011~2.243;P=0.044)及NLR(OR=1.564,95%CI 1.185~2.065;P=0.002)是T2DM患者发生下肢AS的影响因素。多分类logistic回归分析显示,NLR是T2DM患者发生下肢AS 4级的独立危险因素(OR=1.777,5%CI 1.086~2.910;P=0.022);另外,年龄是影响T2DM患者下肢发生不同分级的危险因素,男性患者发生AS 3级和4级的风险分别是女性的4.037和7.819倍;低密度脂蛋白胆固醇和吸烟史是T2DM患者发生AS 3级的危险因素。结论 NLR与T2DM伴有下肢AS密切相关,特别是与T2DM下肢动脉硬化4级密切相关。
英文摘要:
      Objective To investigate the association of neutrophil-lymphocyte ratio (NLR) with grade of arteriosclerosis (AS) in the lower extremities in the patients with type 2 diabetes mellitus (T2DM). Methods A total of 556 T2DM patients admitted to our hospital from September 2017 to September 2018 were recruited in this study, and divided into 4 groups according to the results of AS grading, that is, T2DM+AS1 group (n=140, without AS), T2DM+AS2 group (n=98), T2DM+AS3 group (n=192) and T2DM+AS4 group (n=126). The clinical indices of 4 groups were collected and compared. SPSS statistics 17.0 was used for data analysis. Results Significant differences were seen in age, gender, history of smoking, course of T2DM, history of hypertension, systolic blood pressure (SBP), diastolic blood pressure (DBP), neutrophil count, lymphocyte count, NLR, and levels of creatinine(Cr) and low-density lipoprotein cholesterol (LDL-C) among the 4 groups (P<0.05). Spearman correlation analysis showed that NLR was positively correlated with age, history of hypertension, SBP and Cr level in T2DM AS patients (P<0.05). Binary logistic regression analysis indicated that age (OR=1.111, 95%CI 1.076-1.147; P=0.001), LDL-C (OR=1.506,5%CI 1.011-2.243; P=0.044) and NLR (OR=1.564,5%CI 1.185-2.065; P=0.002) were the influencing factors of lower limb AS in T2DM patients. Multinomial logistic regression analysis suggested that NLR was an independent risk factor for AS grade 4 of the lower extremities in T2DM patients (OR=1.777,5%CI 1.086-2.910; P=0.022), and age was also a risk factor for different grades of AS, and the risk of AS grade 3 and 4 for male patients was 4.037 and 7.819 times higher than that of female patients, respectively; LDL-C and smoking history were risk factors for AS grade 3 in patients with T2DM. Conclusion NLR is closely related with AS in lower extremities in T2DM patients, especially closely related to AS grade 4.
查看全文    下载PDF阅读器
关闭