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中国人民解放军总医院
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中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
刘忠玲,赵培华,张瑞贤,李安民,关文标.高血压患者长时血压变异性对其认知功能的影响[J].中华老年多器官疾病杂志,2019,18(8):607~610
高血压患者长时血压变异性对其认知功能的影响
Effects of long-term blood pressure variability on cognitive function in the hypertensive patients
投稿时间:2019-02-25  
DOI:10.11915/j.issn.1671-5403.2019.08.131
中文关键词:  高血压;血压变异性;认知功能障碍;简易智能精神状态检查量表
英文关键词:hypertension; blood pressure variability; cognitive dysfunction; mini-mental state examination
基金项目:
作者单位E-mail
刘忠玲 甘肃省白银市第一人民医院神经内科,白银 730900 lzl.0716@163.com 
赵培华 甘肃省白银市第一人民医院神经内科,白银 730900  
张瑞贤 甘肃省白银市第一人民医院神经内科,白银 730900  
李安民 甘肃省白银市第一人民医院神经内科,白银 730900  
关文标 甘肃省白银市第一人民医院神经内科,白银 730900  
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中文摘要:
      目的 探讨高血压患者长时血压变异性对认知功能障碍的影响。方法 选取明确诊断为高血压的患者105例,每月定期随诊,专人检测血压1次,随诊12个月后资料收集完整者共97例。根据简易智能检查量表(MMSE)评分,分为认知功能障碍组和正常组;随访1年,同一患者MMSE评分相差≥4分,则为认知功能减退,分为认知功能减退组和无变化组。对各组间的长时血压变异性指标、MMSE评分与长时血压变异性的相关性进行统计学分析。采用SPSS 18.0软件包对数据进行统计学分析。结果 认知功能障碍组长时平均收缩压、平均舒张压、收缩压标准差、收缩压变异性均高于认知功能正常组(P<0.05);MMSE评分与长时平均收缩压、收缩压标准差、收缩压变异性、舒张压变异性负相关(P<0.05);认知功能减退组长时平均收缩压、平均舒张压、收缩压标准差、舒张压标准差、收缩压变异性、舒张压变异性均高于认知功能无变化组(P<0.05)。结论 在高血压患者中,较长时间内血压变异性增大更易导致认知功能障碍的发生。
英文摘要:
      Objective To investigate the effects of long-term blood pressure variability on cognitive function in the hypertensive patients. Methods A total of 105 hypertensive patients were followed up once each month for 12 months, with blood pressure being measured by a specific person on each visit. Complete data were obtained for 97 patients. According to mini-mental state examination (MMSE) score, the patients were divided into the cognitive impairment group and the normal cognitive function group. After one-year follow-up, the patients were divided into cognition decline group (difference of MMSE ≥4 points) and cognition intact group. Statistical analysis was performed for the correlation of long-term blood pressure variability indices, MMSE score with long-term blood pressure variability. Data were processed by SPSS statistics 18.0.Results The systolic blood pressure(SBP), diastolic blood pressure(DBP), the standard deviation of SBP, and the coefficient of variation of SBP in the cognitive impairment group were all higher than those in the normal group. MMSE score was negatively correlated with long-term SBP, standard deviation of SBP and coefficient variation of SBP and DBP. The long-term SBP and DBP, standard deviation of SBP and DBP, coefficient variation of SBP, and DBP in the cognition decline group were all higher than those in the cognition intact group. Conclusion Long-term BPV may contribute to the occurrence of cognitive dysfunction in the hypertensive patients.
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