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中国人民解放军总医院老年心血管病研究所
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
郭朝唤,侯莉明,王宁,王晓明.西安市某社区老年人群衰弱的相关危险因素分析[J].中华老年多器官疾病杂志,2019,18(8):561~564
西安市某社区老年人群衰弱的相关危险因素分析
Risk factors for frailty among community-dwelling elderly in Xi′an
投稿时间:2019-02-13  
DOI:10.11915/j.issn.1671-5403.2019.08.121
中文关键词:  老年人;衰弱;慢性炎症;共病
英文关键词:aged; frailty; chronic inflammation; comorbidity
基金项目:国家自然科学基金(81870184)
作者单位E-mail
郭朝唤 空军军医大学西京医院老年病科,西安 710032  
侯莉明 空军军医大学西京医院老年病科,西安 710032  
王宁 空军军医大学西京医院老年病科,西安 710032  
王晓明 空军军医大学西京医院老年病科,西安 710032 xmwang@fmmu.edu.cn 
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中文摘要:
      目的 探讨西安市某社区老年人群发生衰弱的可能危险因素。方法 对2017年10月至2018年10月西安市某社区卫生服务中心体检≥65岁的老年人群进行横断面调查,运用FRAIL衰弱评估量表(≥3分)筛查并纳入衰弱患者153例(衰弱组)。选取同期在此中心进行健康体检的非衰弱老年人群174名(非衰弱组)。收集并比较2组老年人的基线资料及临床指标。采用SPSS 23.0软件进行统计分析。结果 与非衰弱组比较,衰弱组患者腰围、体质量、体质量指数(BMI)、白细胞计数(WBC)、甘油三酯(TG)、共病发生率、肿瘤坏死因子α(TNF-α)、C-反应蛋白(CRP)水平均显著升高,而高密度脂蛋白胆固醇(HDL-C)显著降低,差异有统计学意义(P<0.05)。相关性分析显示,衰弱程度积分与体质量(r=0.129,P=0.019)、腰围(r=0.196,P=0.000)、BMI(r=0.135,P=0.015)、WBC(r=0.157, P=0.005)、TG(r=0.123, P=0.027)、HDL-C(r=-0.175, P=0.001)、共病数量(r=0.621, P=0.000)、TNF-α(r=0.304,P=0.000)及CRP(r=0.596,P=0.000)显著相关。多元逐步线性回归分析显示,老年人共病数量(B=0.419,95%CI 0.359~0.551;P=0.000)、血清TNF-α水平(B=0.093,95%CI 0.002~0.023;P=0.023)及CRP水平(B=0.374,95%CI 0.370~0.597;P=0.000)为老年人发生衰弱的独立危险因素。结论 西安市社区老年人衰弱的发生可能与患者超重、共病数量及慢性炎症因子水平密切相关。
英文摘要:
      Objective To explore the possible risk factors for frailty in the elderly residents in a community in Xi′an of Shaanxi Province. Methods From October 2017 to October 2018, a cross-sectional survey was conducted among the elderly people over 65 years old who took physical examination in a community health service center in Xi′an. Based on the results of the FRAIL scale (≥ 3 scores), 153 patients were screened out as the frailty group, and another 174 without frail syndrome subjected as non-frailty group. The baseline data and clinical indicators of the 2 groups were collected and compared. SPSS statistics 23.0 was used for data analysis. Results Compared with the non-frailty group, the waist circumference, body mass, body mass index (BMI), white blood cell count (WBC), triglycerides (TG) level, incidence of comorbidities, tumor necrosis factor α (TNF-α) and C-reactive protein (CRP) levels were significantly higher, while the level of high-density lipoprotein cholesterol (HDL-C) was obviously lower in the frailty group (P<0.05). The correlation analysis showed that the score of frailty level was correlated with body mass (r=0.129, P=0.019), waist circumference (r=0.196, P=0.000), BMI (r=0.135, P=0.015), WBC (r=0.157, P=0.005), TG level (r=0.123, P=0.027), HDL-C level (r=-0.175, P=0.001), number of comorbidities (r=0.621, P=0.000), TNF-α (r=0.304, P=0.000) and CRP level (r=0.596, P=0.000). Multivariate stepwise linear regression analysis indicated that the number of comorbidities (B=0.419, 95%CI 0.359-0.551, P=0.000), serum TNF-α level (B=0.093,5%CI 0.002-0.023, P=0.023) and CRP level (B=0.374, 95%CI 0.370-0.597, P=0.000) were independent risk factors for the senile frailty occurrence. Conclusion Overweight, number of comorbidities and levels of chronic inflammatory factors may be the risk factors of frailty among the community-dwelling elderly in Xi′an.
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