在线办公
期刊论坛
主 管
中国人民解放军总医院
主 办
中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
编 辑
中华老年多器官疾病杂志编辑委员会
100853, 北京市复兴路28号
电话:010-66936756
传真:010-66936756
E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
金美林,闫超群,周平,邵佳凯,刘存志.中老年餐后不适综合征患者的临床症状和脑肠肽水平分析[J].中华老年多器官疾病杂志,2019,18(7):481~484
中老年餐后不适综合征患者的临床症状和脑肠肽水平分析
Clinical symptoms and brain-gut peptide level in middle-aged and elderly patients with postprandial distress syndrome
投稿时间:2019-03-19  
DOI:10.11915/j.issn.1671-5403.2019.07.102
中文关键词:  餐后不适综合征;中老年;功能性消化不良;脑肠肽
英文关键词:postprandial distress syndrome; middle-aged and elderly; functional dyspepsia; brain-gut peptide
基金项目:首都临床特色应用研究(Z161100000516007)
作者单位E-mail
金美林 北京中医药大学东方医院针灸科,北京 100078;北京中医药大学针灸推拿学院,北京 100029  
闫超群 北京中医药大学针灸推拿学院,北京 100029  
周平 北京中医药大学针灸推拿学院,北京 100029  
邵佳凯 北京中医药大学针灸推拿学院,北京 100029  
刘存志 北京中医药大学针灸推拿学院,北京 100029 lcz623780@126.com 
摘要点击次数: 54
全文下载次数: 67
中文摘要:
      目的 探讨中老年与青年餐后不适综合征(PDS)患者在中医证候、临床症状和脑肠肽方面的差异。方法 选取2018年3月至2018年10月在北京中医药大学东方医院针灸科就诊的PDS患者65例,将患者分为中老年组(>45岁)和青年组(≤45岁),对2组患者进行中医辨证分型,并分别采用消化不良症状指数(SID)、尼平消化不良指数(NDI)及医院焦虑抑郁量表(HADS)依次评估其消化不良严重程度、生活质量受影响严重程度及焦虑抑郁状态。采用酶联免疫吸附法检测患者血浆中降钙素基因相关肽(CGRP)、血管活性肠肽(VIP)、胃饥饿激素(ghrelin)和P物质(SP)的浓度。采用SPSS 20.0统计软件对数据进行分析。根据数据类型,组间比较采用独立样本t检验、Mann-Whitney U检验或卡方检验。结果 2组患者肝胃不和证、脾胃气滞证、脾胃湿热证构成比比较差异无统计学意义(χ2=4.787,P=0.091)。与青年组比较,中老年组患者上腹烧灼感症状评分[1(0,1)]显著高于青年组[0(0,1)],差异有统计学意义(P<0.05),但其他症状及量表评分在2组患者间比较差异无统计学意义(P>0.05)。中老年组血浆中CGRP浓度[(1.06±0.24)ng/ml]显著高于青年组[(0.93±0.25)ng/ml],差异有统计学意义(P<0.05),但VIP、SP及ghrelin浓度在2组患者间比较差异均无统计学意义(P>0.05)。结论 中老年PDS患者存在较严重的上腹烧心感症状,且血浆中CGRP水平明显升高,这可能与年老导致的胃肠道运动降低及胃肠排空延迟有关。
英文摘要:
      Objective To explore the differences of traditional Chinese medicine (TCM) syndromes, clinical symptoms and brain-gut peptide level between middle-aged and elderly patients with young patients with postprandial distress syndrome (PDS). Methods A total of 65 PDS patients admitted to our Acupuncture Department from March to October 2018 were enrolled in this study, and divided into the middle-aged and elderly group (>45 years old) and the young group (≤45 years old). The 2 groups of patients were classified according to TCM syndrome differentiation. The severities of dyspepsia, quality of life, anxiety and depression were evaluated by symptom index of dyspepsia (SID), Nepean dyspepsia index (NDI) and hospital anxiety and depression scale (HADS), respectively. The plasma levels of calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP), ghrelin and substance P (SP) were measured by enzyme-linked immunosorbent assay (ELISA). The data was analyzed using SPSS statistics 20.0. Depending on the types of data, independent sample t test, Mann-Whitney U test, or Chi-square test was used for comparison between 2 groups. Results There was no significant differences in the compositions of liver-stomach disharmony syndrome, spleen-stomach weakness syndrome and spleen-stomach dampness-heat syndrome between the 2 groups (Chi-square=4.787, P=0.091). The score of epigatric burning symptom was significantly higher in the middle-aged and elderly group than the young group [1(0,1) vs 0(0,1), P<0.05], but no such differences were seen in the other symptoms, and scores of NDI and HADS between them (P>0.05). The plasma level of CGRP was significantly higher in the middle-aged and elderly group than the young group [(1.06±0.24) vs(0.93±0.25)ng/ml, P<0.05], but there was no significant differences in the levels of VIP, SP and ghrelin between the 2 groups (P>0.05). Conclusion The middle-aged and elderly PDS patients experience severe epigastric burning symptom, and have significantly increased[JP+2]plasma CGRP level, which may be associated with ageing-related decreased gastrointestinal motility and delayed gastrointestinal emptying.
查看全文    下载PDF阅读器
关闭