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中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
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中华老年多器官疾病杂志编辑委员会
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E-mail: zhlndqg@mode301.cn
创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
王超,王春光.羟考酮与舒芬太尼复合依托咪酯用于老年男性患者无痛膀胱镜检查效果的比较[J].中华老年多器官疾病杂志,2019,18(1):12~15
羟考酮与舒芬太尼复合依托咪酯用于老年男性患者无痛膀胱镜检查效果的比较
Comparison of oxycodone and sufentanil combined with etomidate for painless cystoscopy in the elderly male patients
投稿时间:2018-08-06  修订日期:2018-11-15
DOI:10.11915/j.issn.1671-5403.2019.01.003
中文关键词:  老年人;羟考酮;舒芬太尼;依托咪酯;膀胱镜
英文关键词:aged; oxycodone; sufentanil; etomidate; cystoscopy
基金项目:保定市科学技术研究与发展指导计划(16ZF070)
作者单位E-mail
王超 保定市第一中心医院麻醉科,保定 071000  
王春光 保定市第一中心医院麻醉科,保定 071000 wangchunguang@163.com 
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中文摘要:
      目的 比较羟考酮与舒芬太尼复合依托咪酯用于老年男性患者无痛膀胱镜检查的效果。方法 选择2017年10月至2018年5月于保定市第一中心医院全麻下行膀胱镜检查的老年男性患者60例,年龄66~78岁,体质量52~74 kg,美国麻醉医师协会(ASA)分级Ⅱ~Ⅲ级,分为2组(每组n=30):羟考酮组(O组)及舒芬太尼组(S组)。O组静脉注射羟考酮0.05 mg/kg,S组静脉注射舒芬太尼0.05 μg/kg,3 min后静脉注射依托咪酯0.2 mg/kg。术中出现皱眉或体动反应时,静脉追加依托咪酯0.1 mg/kg。观察指标:膀胱镜检查过程中患者发生皱眉或体动、呼吸抑制的情况;膀胱镜检查时间及依托咪酯用量;苏醒时间及发生苏醒后头晕、恶心呕吐的情况。采用SPSS 17.0统计软件对数据进行分析。组间比较采用t检验或χ2检验。结果 与S组比较,O组皱眉或体动[10%(3/30) vs 47%(14/30)]及依托咪酯用量[(13.2±2.1) vs (20.7±3.6)mg]减少(P<0.05);与S组比较,O组恶心、呕吐[3%(1/30) vs 20%(6/30)]及呼吸抑制[0%(0/30) vs 13%(4/30)]的发生率均降低(P<0.05);2组头晕[10%(3/30) vs 13%(4/30)]发生率差异无统计学意义(P>0.05)。结论 羟考酮复合依托咪酯可有效用于老年患者膀胱镜检查,效果优于舒芬太尼。
英文摘要:
      Objective To compare the effect of oxycodone and sufentanil combined with etomidate for painless cystoscopy in the elderly male patients. Methods A total of 60 elderly male patients, aged 66 to 78 years, body mass 52-74 kg, American Society of Anesthesiology (ASA) Ⅱ-Ⅲ, were included in the study, who underwent cystoscopy in the Baoding Municipal First Central Hospital from October 2017 to May 2018. The patients were divided into oxycodone group and sufentanyl group with 30 each. The patients were intravenously injected with oxycodone (0.05 mg/kg) in oxycodone group, sufentanyl (0.05 μg/kg) in sufentanyl group, and 3 min later, etomidate (0.2 mg/kg) in both groups. Additional etomidate (0.1 mg/kg) was intravenously administered on frowning or body movement. Indices observed and recorded throughout the procedure included occurrences of frowning, body movement, respiratory depression, duration of cystoscopy, etomidate dosage, wake-up time, dizziness, nausea and vomiting. SPSS statistics 17.0 was used for data processing, and Student′s t-test and Chi-square test were performed for comparison. Results Compared with sufentanyl group, the incidence of frowning or body movement [10%(3/30) vs 47%(14/30)] and the dosage of etomidate [(13.2±2.1) vs (20.7±3.6)mg] decreased in oxycodone group (P<0.05). There was no statistically significant difference between the two groups (P>0.05) in the incidence of nausea and vomiting [3%(1/30) vs 20%(6/30)], respiratory depression [0%(0/30) vs 13%(4/30)] and dizziness [10%(3/30) vs 13%(4/30)]. Conclusion Oxycodone combined with etomidate is more effective than sufentanil for elderly patients undergoing cystoscopy.
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