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中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
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不同剂量阿托伐他汀钙对中重度衰弱高龄老人肌少症的影响
Different dosages of atrovastatin calcium treatment on sarcopenia with moderate to severe frailty in elderly patients
投稿时间:2018-12-12  修订日期:2019-01-17
DOI:
中文关键词:  他汀类;衰弱;肌少症
英文关键词:statins;frailty;sarcopenia
基金项目:江苏省卫生计生委干部保健课题(BJ16034)
作者单位E-mail
李琪 江苏省钟山康复医院 1722163348@qq.com 
李丽丽 江苏省钟山康复医院 1722163348@qq.com 
芮小勇 江苏省钟山康复医院 1722163348@qq.com 
吴剑卿 江苏省人民医院 1722163348@qq.com 
戎其飞 江苏省钟山康复医院 rongqifei@126.com 
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中文摘要:
      目的 观察不同剂量组阿托伐他汀钙对中重度衰弱高龄患者肌少症的影响。以期为高龄且合并衰弱的患者合理用药探索依据。方法 选择98例高龄伴中重度衰弱且正在服用阿托伐他汀钙患者, 随机分为20mg组、10mg组和停药组。检测治疗前后外周血中TG、TC、LDL、HDL浓度;握力;4.5米步行时间;DXA法测四肢肌肉含量(ASM);进行衰弱分级。结果 服药24个月后,20mg组的TC较10mg组及停药组降低且有统计学意义(p值分别为0.041、0.007);24个月后20mg组的LDL-C较10mg组及停药组降低且有统计学意义(p值分别为0.001、0.009);24个月后,20mg组的握力较停药组降低且差异有统计学意义(P=0.000)。10mg组的握力较停药组降低且差异有统计学意义(P=0.000)。24个月后,20mg组的ASMI较停药组降低且差异有统计学意义(P=0.017)。治疗24个月后,20mg组衰弱分级在原有级别上至少上升一级的发生率增高,且差异有统计学意义(P=0.036)。结论 他汀类药物可能进一步加剧增龄相关的肌功能下降和加速衰弱的发生。
英文摘要:
      Objective: To investigate different dosages of atrovastatin calcium treatment on sarcopenia with moderate to severe frailty in elderly patients in order to provide reasonable evidence for its use in elderly sarcopenia patients. Methods: Ninety-eight elderly patients with moderate to severe frailty who were taking atrovastatin calcium were randomly divided into three groups (i.e., 20 mg group, 10 mg group and withdrawal group). TG, TC, LDL, and HDL in the peripheral blood; grip strength testing; 4.5-meter walking time; and appendicular skeletal muscle mass (ASM) by DXA were measured before and after treatment. Frailty levels were also assessed and categorized before and after treatment. Results: After 24 months of treatment, we observed that the TC level in the 20 mg group was significantly lower than that in the 10 mg group and the withdrawal group (p values were 0.001 and 0.009, respectively); the grip strength of the 20 mg group and 10 mg group were significantly lower than that of the withdrawal group ((p values were 0.000 and 0.000, respectively); the ASMI of the 20 mg group was also significantly lower than that of the withdrawal group (P=0.017). Moreover we found that the frailty level in the 20 mg group was increased significantly by at least one level from the original level (P=0.036). Conclusions: Statins may further exacerbate age-related declines in muscle function and accelerate frailty.
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