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中国人民解放军总医院
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中国人民解放军总医院老年心血管病研究所
中国科技出版传媒股份有限公司
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中华老年多器官疾病杂志编辑委员会
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创刊人 王士雯
总编辑 范利
副总编辑 陈韵岱
执行主编 叶大训
编辑部主任 王雪萍
ISSN 1671-5403
CN 11-4786
创刊时间 2002年
出版周期 月刊
邮发代号 82-408
友情链接
早期肝素化对急性前壁心肌梗死直接经皮冠脉介入治疗疗效观察
Effect of early heparin in patients with acute anterior myocardial infarction undergoing primary percutaneus coronary intervention
投稿时间:2018-12-06  修订日期:2019-01-08
DOI:
中文关键词:  肝素化; 心肌梗死;梗死相关动脉;心功能
英文关键词:heparin;myocardial infarction; infarct-related artery;heart function
基金项目:天津市武清区科技发展计划项目
作者单位E-mail
宗文仓 天津市武清区人民医院心内二科 zongwencang@sina.com 
赵毅梅 天津市武清区人民医院 zongwencang@sohu.com 
赵艳辉 天津市武清区人民医院 zongwencang@sina.com 
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中文摘要:
      [摘要] 目的:探讨早期肝素化对急性前壁心肌梗死患者梗死相关动脉血流及心功能的影响。方法:连续入选天津市武清区人民医院2017年4月—2018年11月收治的急性前壁心肌梗死患者100例,采用随机数字表方法,将患者分为观察组和对照组,每组50例。观察组患者在急诊科静脉注射普通肝素4000u,对照组患者在导管室经鞘管普通肝素4000u。所有患者均接受了急诊经皮冠脉介入治疗(PCI)。观察2组患者肝素给药时间、术前活化凝血时间(ACT)、冠脉造影梗死相关动脉血流情况、D-to-B时间、血管开通时间、高敏肌钙蛋白T(hs-cTnT)峰值、B型脑钠肽前体(ProBNP)峰值、住院期间泵衰竭、左室射血分数(LVEF)、住院天数。结果:观察组患者造影即刻TIMI0级比例、D-to-B时间、血管开通时间、高血栓负荷比例、hs-cTnT峰值、ProBNP峰值、住院泵衰竭比例、住院天数明显低于对照组,差异均有统计学意义(P<0.05);观察组患者首次肝素给药时间、ACT、TIMI2~3级比例、LVEF明显高于对照组,差异均有统计学意义(P<0.05)。结论:早期肝素化可提高急性前壁心肌梗死患者罪犯血管再通率,缩短血管开通时间,改善心功能。
英文摘要:
      ABSTRACT : To study the effect of early heparin on blood flow of infarct-related artery and heart function in patients with acute anterior myocardial infarction .methods One hundred patients admmitted to our hospital were randomly divided into observation group with fifty cases and control group with fifty cases. They underwent intravenous injection with 4000U unfractionated heparin in observation group while not that in control group.The heparin administration time, activated coagulation time ,blood flow of infarct-related artery, door to balloon time,vessel opening time, troponin T peak,ProBNP peak,pump failure,and left ventricular ejection fraction were recorded in two groups.Results The ratio of TIMI 0 ,door to balloon time, vascular operation time, ratio of high thrombosis load,peak of troponin T, peak of ProBNP and length of stay in observation group was lower than that in control group, there was significantly differenc between the two groups(P<0.05).The heparin administration time,activated coagulation time, ratio of 2~3 grade, left ventricular ejection fraction in observation group was higher than that in control grouin observation group, here was significantly differenc between the two groups(P<0.05).No significant difference in the incidence of slow blood flow between the two groups (P>0.05)..Conclusion Early heparin can increase recanalization of culprit vessel, shorten vascular operation time, improve heart function in acute anterior myocardial infarction patients.
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